L-5-MTHF provides 1 mg (1,700 mcg DFE) of natural, biologically active form of folate, which is essential for cell division and growth, and also works to balance the homocysteine pathway. This formula provides folate in the bioidentical, bioactive form, 5-methyltetrahydrofolate. In L-5-MTHF, the “L” signifies that it is an all-natural [6S] isomer, and this is the active circulating form of folate found in the body and one of the several forms found in food. In nature, this is found only as this [6S] isomer, which is why Designs for Health uses L-5-MTHF, the natural isomer, rather than the mixed (or racemic) form. This product uses the patented folate derivative, Quatrefolic. This innovative form of folate has demonstrated high bioavailability, solubility, and long-lasting stability. Quatrefolic L-5-MTHF has been shown to help increase blood folate levels much better than folic acid.

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††An IPSOS 2023 survey among US functional medicine practitioners, in an average month, Designs for Health is their personally most trusted practitioner supplement brand, meaning a brand that is sold by healthcare practitioners in their office.

††An Ipsos 2023 study among a random sample of 160 functional medicine practitioners including Doctor's of Osteopathic Medicine, Pharmacists, Acupuncturists, Athletic Trainers, Personal Trainers, Fitness Trainer/Coaches, Chiropractors, Integrative Medicine Specialists, Naturopathic Doctor, Homeopaths, Medical Doctors, Physical Therapists, Nurse Practitioner/Physician Assistants, Registered Nurses, Nutritionists, Massage Therapists, Occupational Therapists and Dieticians that are aware of Designs for Health and recommend supplements to their patients.

At Wellness Supplement, we strive to provide up-to-date product information and images on our website. However, please be aware that manufacturing changes to packaging or ingredients may occasionally occur before updates are reflected on our site.

Products may ship with different packaging due to recent updates from the manufacturer or supplier. In most cases, the ingredients remain the same despite the packaging change. However, we strongly recommend reading all labels, warnings, and directions before use. Please do not rely solely on the information provided on Wellness Supplement’s website.

Probiotics are shipped with a free ice pack. While the product may not be cold upon delivery, the ice pack helps maintain a cooler temperature during transit. Please consider weekend and holiday delays when placing an order. 

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