Glucosamine is required for the synthesis of proteoglycans, the molecules responsible for providing tendons, ligaments, and cartilage their resiliency and strength. It also helps protect cartilage from the effects of mechanical stress. Sulfate, another component of proteoglycans, works synergistically with glucosamine to enhance cartilage repair and regeneration. BioCell Collagen provides hydrolyzed and denatured low molecular weight collagen. Additionally, it provides a naturally occurring blend of hyaluronic acid (HA), chondroitin sulfate, glucosamine sulfate and amino acids to promote cartilage synthesis and joint integrity. A double-blind, placebo-controlled study involving 16 individuals supplementing with BioCell Collagen for eight weeks indicated statistically significant support for joint function and comfort. To further encourage collagen formation, this formula is enhanced with l-lysine and l-proline. These amino acids are hydroxylated to form hydroxyproline and hydroxylysine in a reaction involving vitamin C, forming the "glue" that holds collagen together. In the body, silica is found primarily in connective tissue and plays a role in collagen tissue formation. Devil's claw and curcumin are included to support joint flexibility, function and comfort, in part by maintaining healthy eicosanoid metabolism.