HMRlignan contains the lignan 7-hydroxymatairesinol, a precursor to enterolactone, which has been associated with a healthy estrogen-to-progesterone ratio and cellular health. As a result, lignans have demonstrated supportive roles in moderating hot flashes as well as promoting breast, uterine, cervical, bone and cognitive health. Importantly, dietary intake of lignans and healthy serum enterolactone levels are also positively associated with healthy cardiovascular function. Lifenol hops extract contains 8-prenylnaringenin (8-PN), offering support for menopausal comfort, antioxidant defense and bone health. Two randomized, double-blind, placebo-controlled studies indicated that Lifenol hops extracts provided support for general menopausal discomfort, night sweats and hot flashes. Questionnaire results scored at six to eight weeks after supplementation suggest that hot flashes were reduced by three to four times compared to placebo.Ashwagandha, Rhodiola rosea and maca extracts are adaptogens offering support for relaxationduring times of occasional stress. Two randomized controlled trials indicated that ashwagandha offers support for occasional stress, maintaining healthy sleep, cognitive function and relaxation. Maca offers support for sexual function. While Rhodiola has long been known to support endurance, it may also support menopausal comfort by acting as a selective estrogen receptor modulator. In a preliminary, randomized controlled pilot trial, resveratrol supplementation decreased menopausal symptom intensity in 78.6% of patients. Multiple studies suggest that grape seed polyphenols promote healthy blood vessel relaxation and antioxidant defenses to support cardiovascular health.