Nitric Oxide Support is an arginine-based formulation designed to support healthy nitric oxide production, facilitate ammonia and lactate removal to moderate fatigue, maintain acid-base balance and provide antioxidant protection. Arginine, a precursor of nitric oxide, supports healthy circulation by promoting endothelial function, blood vessel tone and healthy platelet function, as indicated in several randomized cross-over trials. l-Citrulline is a non-essential amino acid that is converted to arginine, enhancing nitric oxide production. Vitamin C has a dual role, helping to enhance nitric oxide bioavailability and activity as well as providing blood vessel endothelial antioxidant protection. This formula offers Krebs cycle intermediates in the form of alpha ketoglutarate and malate for additional energy support. Arginine may protect muscles from oxidation and moderate lactate dehydrogenase activity during intense exercise. In one study, citrulline malate provided potential support for aerobic energy production and fatigue reduction. Double blind, placebo-controlled studies indicate that arginine and citrulline helps lessen muscle fatigue and maintain healthy acid-base balance, primarily by serving as intermediates in the urea cycle, which helps to eliminate ammonia.