Probiotics are integral to immune health, stimulating antibody production and cell-mediated immunity. Research indicates that probiotics may enhance B cell, T cell and NK cell function, phagocytic capacity and activity, and healthy cytokine production. A recent meta-analysis involving 9 randomized controlled trials has revealed that probiotics maintain healthy immune and nasal function. These strains provide support for a healthy immune response and immunoglobulin function. B. longum BB536 is a shelf stable probiotic in Japan, supported in the literature by over 25 human trials and 30 animal studies. Double blind, placebo-controlled trials indicate that B. longum BB536 supplementation maintains GI bacteria balance, supporting immune function and maintaining eye, nose and throat health. In another randomized, double blind, placebo-controlled trial, L. acidophilus and B. lactis showed support for nasal function and maintained healthy eosinophil activity within the nasal lining. Research involving B. bifidum, L. casei and L. plantarum also suggests that these strains maintain healthy cytokine production, IgE function and mast cell integrity.